woah, bad decision it's bad, the best advice you can get for the next time it's that, if you don't know anything about a PC or gaming on a PC (since you don't know what a Quadro FX is and how old it is and how it simply doesn't meet the minimun game requirements), just don't buy any game at all and get it for console, it's easier that way
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EDIT: Does the fact that I have it installed on an external harddrive make a difference?
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no it doesn't, drivers are related to the operating system, not the game itself, you can't run Dragon age: origins on that setup, period, not much to discuss there