I've never used Combos, but switching monsters is done by clicking on the next monster after you've fired the skill that will kill the target (it doesn't really matter if it doesn't do the kill, but the monster will continue to attack you until you finish it off), but before the target is actually killed. If your target dies the combo is finished, so you need a new target before that happens. Probably needs a bit of practice since you'll probably place the camera and mousepointer towards the next target while still doing the tricky combo thing (it's always been too complicated for me, so I didn't use it).
Also, the range in the combo bar that you have to hit decreases with every hit, but only until 11. After that the range stays the same.
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