This thread is depressing. I'll answer with video games.
Being charged by a buffalingo while you're fighting a rathalos. (Monster Hunter)
CC-locked by a rogue in WoW.
Dying from the poison in Tales of Maj'Eyal after having defeated the boss that poisoned you (this also applies to the lightning DoT of Urkis)
Getting bitten by that one geographer you didn't notice in the bush(Ragnarok Online).
(makes me scream f*** everytime ._.)
Last edited by DarkAztaroth; 02-16-2014 at 08:26 PM.