Oddly enough, not as bad as one would assume. I'm still overweight (lost quite a bit earlier this year when I switched to vegetarian...summer ruined my veggieness, but winter will probably have me back on it. ****in' BBQ's man...) but doc says I'm good every time I go in for a sniffly cold or whatever.
My knees and shoulders and fingers are all pretty smashed up though. I have a really bad knee (jumped off a huge sand dune and wrecked it, never been the same since) and a bad shoulder...I really need surgery (pins in the shoulder) but I can't afford it. It's whatever...I just can't throw stuff really hard. Or walk sometimes when my knee decides to pop out.
Other than that, I have a brain thing pseudotumor...I dunno how that's going. I've always had it, but it turns out THC is one of the things that helps it. So yeah, I don't get the symptoms and it keeps it consistently in check.