Although, yeah it just depends on play style. There's also the whole philosophy shtick, like I prefer dealing the biggest amount of damage, so I run around with a Rocket Roulette and Poseidon. Doesn't get me much of a high K/D ratio but meh, I loves em to death.
Just remember, any setup is good as long as ya understand what it's supposed to do. If'n ya don't, then either the design's bad or you're using it wrong.
Nubspitters x2 if you like sleeping at your computer and do not posses skill of any kind. Anything else if you are any good at fps games. Personaly Rockets because they are the only weapon the dont require a lock on, they actualy work like a real gun and hit a small AOE + they can hit targets at point blank.
Lol, Callin pretty much said what a lot of people would generally say. Although a lot of people use spitters, you have to take notice that most people who are in the top don't use spitters. I for one use Annihilator+SMG, and dual chargers. Healing is fun, and you usually get 1st or 2nd if you know when to heal and when to attack.