This guide is mainly useful for new players, and some level 30's.
1) Complete the Rune Mysteries Quest - "This has to be the EASIEST quest ever, it just involves running back and forth, only takes like 8 minutes to complete."
2) Bring a Pickaxe - "Self explanatory"
3) Mine about 1000 Rune Essence - "No joke, this only takes an 1 hour, even though you'll be filling up your inventory with 28 Rune Essence every run, you'll eventually get it. But the time-frame is only 1 hour/1 hour and a half."
4) Head to the Grand Exchange and Sell - "People pay BIG for Rune Essence, ever since the Grand Exchange, you could make TONS of cash easily. Even regular logs sell for about 20 coins each! [Note: Rune Essence cost 34 gp each in the Grand Exchange, which is the optimal price. You could max the price out or lower it to the least, either way is fine]."
5) Wait for a buyer...- "Yep..."
6) Repeat if needed - "You could afford a full Rune Armor Set with 60k at the Grand Exchange. This has to be one of the easiest money makers out there, so, enjoy!"