Slides in the presentation mention two large areas that make up the bulk of Witcher 3's world: Novigrad and Skellige. Novigrad clocks in at around 72 square kilometers, with Skellige's size estimated at 64 square kilometers. Together, the two combine to form a game world that covers 136 square kilometers, or roughly 52 square miles.
Members of gaming forum NeoGAF crunched the numbers on world sizes for various other open-world games, and the results are astounding. Skyrim's game world, for example, is only around 39 square kilometers, making Witcher 3's world roughly 3.5 times larger than that of Bethesda's open-world epic. In fact, the only modern game (if we aren't counting games that map the vast reaches of space, like Elite: Dangerous) that even comes close to the size of Witcher 3 is GTA V, with its 81 square kilometer world. Even then, Witcher 3 is 1.5 times larger.