I have to echo the Les Claypool love. The guy is just constantly creative, and not even I give him enough respect. (I haven't bought one of his nigh ten plus solo releases, only sticking to Primus stuff.)
Next, I'm going to say Flea from the Red Hot Chili Peppers.
Let me be clear with this: I no longer respect them as a band. They have fallen too far into pop for me to give a shit about them, but I can't disrespect Flea. In too many of their horrific pop ballads, Flea is the only person keeping the songs from being untolerable.