Perhaps if they used the Infared somehow..MAYBE. BUT COME ON, a Wiimote is easier to hack and reprogram.

PSP Homebrews can run emulators, not exactly sure how 100%, but they
are indeed .exe files. Global MapleStory needs Gameguard to run as well.
I can imagine how hard it will be to run it off a Memory Stick, let alone the
Wifi connection.